High-resolution manometry thresholds across the lower oesophageal sphincter

High-resolution manometry thresholds across the lower oesophageal sphincter

Defining high-resolution manometry thresholds of backward pressure across the lower oesophageal sphincter through straight leg raise maneuver predictive of pathologic acid exposure time.

Study status  – Fully recruited, now in analysis phase


High resolution manometry (HRM) is a key test in the preoperative assessment of patients with gastro-oesophageal reflux (GORD) disease who are potential candidates for antireflux surgery. The recent Lyon consensus suggested the potential usefulness of HRM in diagnosing GORD, however, sensitivity and specificity of HRM for GORD remains low. Among recently proposed provocative tests during manometry, a traditional maneuver (straight leg raise maneuver) appeared promising in predicting reflux. This study aims to predict if the straight leg raise maneuver can predict pathological oesophageal acid exposure time.

Inclusion Criteria

To participate you must meet the following criteria:

  1.  Aged 18-75 years
  2. BMI less than 35kg/m2
  3. Not have a large hiatus hernia (smaller than 3cm)
  4. No previous foregut surgery
  5. Undergoing Oesophageal Manometry and 24hr pH studies at The Functional Gut Clinic

Other medical conditions, pregnancy or treatments may exclude you from taking part in the study. This will be assessed in more detail before enrolment in the study.


The Functional Gut Clinic, 262 Deansgate, Manchester, M3 4BG

The Functional Gut Clinic, 22 Upper Wimpole Street, London, W1G 6NB

Participant involvement

The study will be conducted whilst attending the clinic for the Oesophgeal manometry. The patient will be asked to complete questionnaires related to their health and reflux symptoms. During the oesophageal manometry the paitent will be led down and asked to raise one leg to an angle of 45 degrees for at least 5 seconds. This will then be repeated.


There are no direct benefits from partaking in the study, however, information we get from this study will help predict pathological oesophgeal acid exposure time.

Contact details 

Jordan Haworth – Jordan@functionalgutdiagnostics.com