FAQ

  • WHAT IS IBSchek?

    IBSchek is a simple ELISA*-based blood test that is highly predictive of an IBS-D diagnosis based on the presence of one or two antibodies—anti-CdtB and/or anti-vinculin. Results of a study of more than 2,500 patients conducted in 180 centres across the United States confirmed that IBSchek is the only quick and reliable blood test for the diagnosis of IBS-D.
    *ELISA=enzyme-linked immunosorbent assay.

  • HOW DOES IBSchek WORK?

    IBSchek tests for the presence of two antibodies—CdtB (cytolethal distending toxin B) and vinculin—that were created from a previous episode of acute gastroenteritis. The two levels are complementary and together enable a differential diagnosis of IBS-D from Inflammatory Bowel Disease.

  • WHAT DOES A POSITIVE IBSchek MEAN?

    A positive IBSchek confirms—with a high degree of medical certainty—that your patient has IBS-D and that his or her disease is real. This may prevent treatment delays and keeps patients from having to undergo more invasive and costly exploratory tests.
    It is important to note that IBSchek does not offer insight into which treatment is best for your patient with IBS-D. However, confidently knowing your patient has IBS-D allows you to immediately initiate therapy without additional invasive and costly testing.
    You may want to consider a Hydrogen/Methane Breath Test (HMBT) for Small Intestinal Bacterial Overgrowth (SIBO) to help determine the type of antibiotic therapy to use. Treatment of a patient with methane-positive breath results differs from that of a patient with hydrogen-positive results. Once the SIBO is identified, an appropriate antibiotic regimen can be prescribed for the treatment of Irritable Bowel Syndrome.

  • WHAT IF IBSchek IS INCONCLUSIVE?

    Although IBSchek is highly predictive of an IBS-D diagnosis, some patients that you suspect may have IBS-D will still have an inconclusive test result.
    An inconclusive IBSchek result confirms that the IBS phenotype is not linked to the CdtB bacterial toxin that was produced from a previous acute gastroenteritis. It is also simply an indication that additional testing is required to determine the cause of your patient’s symptoms.

  • CAN MEDICATIONS AFFECT IBSchek RESULTS?

    Yes, some medications can affect the results of an antibody test, including IBSchek. It is important to note that steroids, anti-inflammatory medications, biologic agents, or any other immunosuppressive medications may change the level of antibodies in the blood and therefore influence the IBSchek test results. Only you, as the physician, may decide whether or not to ask your patient to stop taking these agents.
    If a patient with suspected IBS-D has an inconclusive test and is taking any of these medications, repeat testing could be considered at a time when the patient is no longer taking these medications.

  • IS THERE A LINK BETWEEN IBS-D AND SMALL INTESTINAL BACTERIAL OVERGROWTH?

    It is now known (based on extensive human and animal research) that acute gastroenteritis leads to IBS-D. In animal studies, infection with Campylobacter jejuni caused Small Intestinal Bacterial Overgrowth (SIBO). C. jejuni infection also may cause production of the anti-CdtB and anti-vinculin antibodies detected by IBSchek. In the same animal studies, antibody levels were related to the number of infections the animals experienced. However, regardless of the number of infections with C. jejuni, bacterial overgrowth was more closely related to the antibodies than to the number of infections.
    One option that may be a viable consideration is the Hydrogen/Methane Breath Test (HMBT) for SIBO. The HMBT can identify an over-colonization of microbes in the small intestine that may be directly contributing to a patient’s symptoms. HMBTs not only offer a patient-friendly alternative to more invasive diagnostic methods, but once the SIBO is identified, an appropriate antibiotic regimen can be prescribed.

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